Information about Lariam.<\/h2>\n<\/p>\n

Two metabolites have been identified in humansThe main metabolite2,8bistrifluoromethyl-4-quinoline carboxylic acidis inactive in Plasmodium falciparumIn a study in healthy volunteersthe carboxylic acid metabolite appeared in plasma 2 to 4 hours after a single oral doseMaximum plasma concentrationswhich were about 50higher than those of mefloquinewere reached after 2 weeksThereafterplasma levels of the main metabolite and mefloquine declined at a similar rateThe area under the plasma concentration-time curveAUCof the main metabolite was 3 to 5 times larger than that of the parent drugThe other metabolitean alcoholwas present in minute quantities only.<\/p>\n

In patients taking an anticonvulsantegvalproic acidcarbamazepinephenobarbital or phenytointhe concomitant use of Lariammefloquinemay reduce seizure control by lowering the plasma levels of the anticonvulsantThereforepatients concurrently taking antiseizure medication and Lariammefloquineshould have the blood level of their antiseizure medication monitored and the dosage adjusted appropriatelysee PRECAUTIONS<\/p>\n

Liver problemsnauseaupper stomach painitchingtired feelingloss of appetitedark urineclay-colored stoolsjaundiceyellowing of the skin or eyes<\/p>\n

If you are taking Lariam to prevent malariayou should also take steps to avoid mosquito bitesSome information on how to avoid bites is given belowThis is important as no medicine can be 100guaranteed to protect you against malaria.<\/p>\n

Please seek medical help immediately if you experience serious mental problems while taking LariamLariam should be stopped immediately and replaced with another medicine to prevent malaria.<\/p>\n

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