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The dose-response relationship for orlistat in human volunteers is shown in Figure 1The effect is the percentage of ingested fat excretedreferred to as fecal fat excretion percentageBoth individual dataopen circlesand the curve predicted for the population with the maximum-effect modelcontinuous lineare shown in Figure 1.
This list is not completeOther drugs may interact with orlistatincluding prescription and over-the-counter medicinesvitaminsand herbal productsNot all possible interactions are listed in this medication guide.
Table 3Other Treatment-Emergent Adverse Events From Seven Placebo-Controlled Clinical Trials.
Hypothyroidism has been reported in patients treated concomitantly with XENICAL and levothyroxine postmarketingPatients treated concomitantly with XENICAL and levothyroxine should be monitored for changes in thyroid functionAdminister levothyroxine and XENICAL at least 4 hours apartsee DOSAGE AND ADMINISTRATION
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