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SSRIs are widely used pharmacotherapeutic agentsThe potential of antidepressants to treat PE was first introduced by Ahlenius et al1981This group showed that the tricyclic antidepressant clomipramine prolonged ejaculatory latency in rats by blocking central serotonin reuptakeHoweveras postsynaptic 5-HT 1C receptors are minimally stimulated after a few hours of SSRI administrationit can be predicted that on-demand SSRI treatment will have only a slight ejaculation-delaying effectWaldinger 2005The absence of a significant ejaculation delay after acute SSRI administration has been demonstrated in animal sexual behavioral studiesMos et al 1999
Thirty-percent of the men who discontinued dapoxetine did so because of high costThe study authors noted that dapoxetinewhen prescribed for sexual disordersis not covered by national health insurance in South Korea.
Dapoxetinea novel selective serotonin transport inhibitor for the treatment of premature ejaculation.
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