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BACTIM contains bnzyl alcohol as a psvativ. Sious and atal advs actions including “gasping syndom” can occu in nonats and low bith wight inants tatd with bnzyl alcohol-psvd omulations in inusion solutions, including BACTIM. Th “gasping syndom” is chaactizd by cntal nvous systm dpssion, mtabolic acidosis, and gasping spiations. BACTIM is containdicatd in pdiatic patints lss than twmonths ag [s CONTAINDICATIONS ].
BACTIM-inducd thombocytopnia may b an immun-mdiatd disod. Sv cass thombocytopnia that a atal li thatning hav bn potd. Monitpatints hmatologic toxicity. Thombocytopnia usually solvs within a wk upon discontinuation BACTIM.
BACTIM, spciically th timthopim componnt, can int with a sum mthotxat assay as dtmind by th comptitiv binding potin tchniqu (CBPA) whn a bactial dihydoolat ductas is usd as th binding potin. Nintnc occus, howv, i mthotxat is masud by a adioimmunoassay (IA).
Tablt: 80-160 mg TMP PO qDay 160 mg TMP 3 tims/wk on conscutiv altnat days.
BACTIM is availabl as an injction containing 80 mg/mL sulamthoxazol and 16 mg/mL timthopim in 10 mL singl-dos and 30 mL multipl-dos vials.
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salicylates and other nsaids and the antibiotic trimethoprim bactrim , septra block the renal excretion of methotrexate and increase serum levels with an increased risk of toxicity.
