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In patients with bipolar disordertreating a depressive episode with ZOLOFT or another antidepressant may precipitate a mixed/manic episodeIn controlled clinical trialspatients with bipolar disorder were generally excludedhoweversymptoms of mania or hypomania were reported in 0.4of patients treated with ZOLOFTPrior to initiating treatment with ZOLOFTscreen patients for any personal or family history of bipolar disordermaniaor hypomania.
When treating a pregnant woman with ZOLOFT during the third trimestercarefully consider both the potential risks and benefits of treatmentMonitor neonates who were exposed to ZOLOFT in the third trimester of pregnancy for PPHN and drug discontinuation syndromeSee Data
Overallavailable published epidemiologic studies of pregnant women exposed to sertraline in the first trimester suggest no difference in major birth defect risk compared to the background rate for major birth defects in comparator populationsSome studies have reported increases for specific major birth defectshoweverthese study results are inconclusiveSee DataThere are clinical considerations regarding neonates exposed to SSRIs and SNRIsincluding ZOLOFTduring the third trimester of pregnancySee Clinical Considerations
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