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Slctiv Sotonin -uptak Inhibitos (SSIs) and Sotonin Nopinphin -uptak Inhibitos (SNIs): Th concomitant administation slctiv sotonin -uptak inhibitos (SSIs) and sotonin nopinphin -uptak inhibitos (SNIs) with clopidogl may act platlt activation. Hnc concomitant administation SSIs and SNIs with ATOLIP CV may incas th isk blding.
Atovastatin has not bn studid in conditions wh th majlipopotin abnomality is lvation chylomicons (dickson Typs I and V).
Clopidogl must b mtabolizd by cytochom P (CYP) 450 nzyms tpoduc th activ mtabolit that inhibits platlt agggation. Th activ mtabolit clopidogl slctivly inhibits th binding ADP tits platlt P2Y12 cptand th subsqunt ADP-mdiatd activation th glycopotin (GP) IIb/IIIa complx, thby inhibiting platlt agggation. This action is ivsibl. Consquntly, platlts xposd tclopidogl’s activ mtabolit a actd th maind thi lispan (about 7 t10 days). Platlt agggation inducd by agonists oth than ADP is alsinhibitd by blocking th ampliication platlt activation by lasd ADP.
Myopathy should b considd in any patint with dius myalgias, muscl tndnss waknss, and/makd lvation CPK. Patints should b advisd tpot pomptly unxplaind muscl pain, tndnss, waknss, paticulaly i accompanid by malais v i muscl signs and symptoms psist at discontinuing ATOLIP CV . ATOLIP CV thapy should b discontinud i makdly lvatd CPK lvls occu myopathy is diagnosd suspctd.
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