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Data from clinical trials in patients indicate that the plasma concentrations of galantamine in patients with Alzheimer’s disease are 30to 40higher than in healthy young subjects primarily due to the advanced age and reduced kidney functionBased upon the population pharmacokinetic analysisclearance in female subjects is 20lower as compared to malesThe galantamine clearance in poor metabolisers of CYP2D6 is about 25lower than in extensive metabolisersbut no bimodality in the population is observedThereforethe metabolic status of the patient is not considered to be of clinical relevance in the overall population.
Non-clinical data suggest no special hazard for humans based on conventional studies of safety pharmacologyrepeated dose toxicitygenotoxicity and carcinogenic potential.
Heart problemsincluding changes in heart beatsuch as a slow beatextra beatsor palpitationsheart beat feels fast or unevenHeart problems may show as an abnormal tracing on an electrocardiogramECGand can be common in people taking Reminylmay affect up to 1 in 10 peopleFitsseizuresThese are uncommon in people taking Reminylmay affect up to 1 in 100 peopleYou must stop taking Reminyl and get help immediately if you notice any of the side effects aboveOther side effectsVery Common side effectsmay affect more than 1 in 10 peopleNausea and vomitingThese side effects are more likely to happen in the first few weeks of treatment or when the dose is increasedThey tend to disappear gradually as the body gets used to the medicines and generally only last for a few daysIf you have these effectsyour doctor may recommend that you drink more liquids and may prescribe a medicine to stop you being sick.
Check with your doctor before you stop taking ReminylIt is important to continue taking this medicine to treat your condition.
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