Patients treating hepatitis c with copegus ribavirin may experience side effects, such as .
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Pegasys is a new generation hepatitis C therapyIn combination with CopegusPegasys is the only pegylated interferon that offers all patient groupsgenotype 1 and non-1even with difficult-to-treat advanced liver diseaseCompared to standard interferon it offers more patientswith even difficult-to-treat and advanced liver diseasea better chance of a cure when compared with non-pegylated interferonIt is given once-weekly by injection and compared to standard combination therapyPegasys is associated with a significant reduction in the incidence of certain side-effects such as flu-like symptomsdepression and hair loss.
10Shiffman MBisceglie ALinsay Ket alPeginterferon alfa-2a and ribavirin in patients with chronic hepatitis C who have failed prios treatmentGastroenterology 2004126:1015-233Links
Problems with your visionfeverchillsbody achesflu symptomssevere pain in your upper stomach spreading to your backnausea and vomitingfast heart ratestabbing chest painwheezingfeeling short of breathsevere depressionhallucinationsthoughts of suicide or hurting yourselfchest pain or heavy feelingpain spreading to the arm or shouldernauseasweatinggeneral ill feelingor pale or yellowed skindark colored urineeasy bruising or bleedingconfusionor unusual weakness.
Peginterferon alfa plus ribavirin is currently the treatment of choice for chronic hepatitis CPeginterferon alfa-2a40KDplus ribavirin has given an overall sustained virological response of 18in F3/F4 previous nonresponder US patientsWe evaluated the effectiveness of peginterferon alfa-2a40KDplus ribavirin in Brazilian patients who were relapsers or nonresponders to previous interferon-based therapyOne-hundred-thirty-four patients with biopsy-proven chronic hepatitis CHCV RNA positiveelevated ALT and who were either relapsersn=37or nonrespondersn=97to at least 24 weeks of conventional interferon/ribavirin therapy were retreated with peginterferon alfa-2a40KD180mg/qw and ribavirin 800mg bid for 48 weeksEfficacy was assessed as virological responsedefined as undetectable HCV RNAat the end of treatmentEoTand at the end of follow-upSVRSustained Virological ResponseSafety assessments consisted of clinical and laboratory evaluationsIn the patient sample72were genotype 1 and 34were cirrhoticIn an intention-to-treat analysisrelapser patients showed 78EoT response and 51SVRNonresponders showed 57EoT response and 26SVRPositive predictive factors of SVR were non-1 genotype and relapser stateSix percent of the patients interrupted treatment because of adverse events and 45had dose reductionmainly associated with leucopenia and anemiaBrazilian patient relapsers and nonresponders to conventional interferon and ribavirin treatment can achieve a sustained virological response when retreated with peginterferon alfa-2a40KDand ribavirinThe safety profile is similar to that of naive patients.
If you have these symptomstalk to your doctor right awayBlood tests can help your doctor determine whether you have lactic acidosis.
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